Super Globals
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[signature] => Taining in large cortical pyramidal neurons (B) and hippocampal pyramidal neurons (C). APP staining appears to demarcate the margins of CA2 pyramidal neurons, which were largely devoid of staining (C). Low power (2? micrograph of an adjacent section stained with an anti-GFAP antibody. GFAP staining reveals the presence of glia and astrocytes within the neocortex and hippocampus (D). Higher power (20? images from the cortex (E) and hippocampal dentate gyrus (F) are shown for comparison to (B-C) and illustrate that human APPSw/Ind expression in SD-169 occurring predominately in neurons.Page 7 of(page number not for citation purposes)BMC Neuroscience 2008, 9:http://www.biomedcentral.com/1471-2202/9/vulnerable to neuropathological insult in AD. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19118039 We determined that the eGFP signal consistently appears to be both nuclear and cytoplasmic in vitro and in vivo, regardless of the method of transgene delivery or type of promoter. Similar results were obtained by Wei et al. [23], who showed that eGFP diffused bidirectionally via the nuclear pore complex across the nuclear envelope. To our knowledge, this is the first inbred, APP-transgenic rat model of AD that has substantial quantities of A in serum. Prior to the generation of APP21 and APP31 transgenic rat strains, a Fischer 344 inbred AD model expressing APP (TgAPPSw) was reported by Ruiz-Opazo et al. [13]. However, APP expression in these TgAPPSw rats was only 56 greater than in WT rats. In addition, APP-transgenic%2
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[signature] => Taining in large cortical pyramidal neurons (B) and hippocampal pyramidal neurons (C). APP staining appears to demarcate the margins of CA2 pyramidal neurons, which were largely devoid of staining (C). Low power (2? micrograph of an adjacent section stained with an anti-GFAP antibody. GFAP staining reveals the presence of glia and astrocytes within the neocortex and hippocampus (D). Higher power (20? images from the cortex (E) and hippocampal dentate gyrus (F) are shown for comparison to (B-C) and illustrate that human APPSw/Ind expression in SD-169 occurring predominately in neurons.Page 7 of(page number not for citation purposes)BMC Neuroscience 2008, 9:http://www.biomedcentral.com/1471-2202/9/vulnerable to neuropathological insult in AD. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19118039 We determined that the eGFP signal consistently appears to be both nuclear and cytoplasmic in vitro and in vivo, regardless of the method of transgene delivery or type of promoter. Similar results were obtained by Wei et al. [23], who showed that eGFP diffused bidirectionally via the nuclear pore complex across the nuclear envelope. To our knowledge, this is the first inbred, APP-transgenic rat model of AD that has substantial quantities of A in serum. Prior to the generation of APP21 and APP31 transgenic rat strains, a Fischer 344 inbred AD model expressing APP (TgAPPSw) was reported by Ruiz-Opazo et al. [13]. However, APP expression in these TgAPPSw rats was only 56 greater than in WT rats. In addition, APP-transgenic%2
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)
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